MESOPOROUS SILICA NANOPARTICLES AS PROMISING NANO CARRIERS- AN OVERVIEW

Pasam Jyothirmayi*, Abbineni Anusha, V. Sushma, V. Sirisha, K. Sravani, G. Nagalakshmi and B. Kalyani

ABSTRACT

Mesoporous silica nanoparticles (MSNs) are silica nanoparticles with large surface area and pore volume have attracted considerable attention for their application in drug delivery and biomedicine. MSN’s have wide applicability as immediate, sustained, controlled and targeted drug delivery systems. The structure, morphology, size, and surface properties of MSNs have been found to be facilely tunable for the purposes of drug loading, controlled drug release and delivery, and multi fuctionalization. Meanwhile, the characteristics, various factors of MSN’s, drug loading and synthesis methods and evaluation are the major parameters to study MSN’s as drrug carriers. MSN’s have biosafety and in vivo drug efficiency of MSN-based nano drug delivery systems (nano-DDSs), involving biocompatibility and pharmacokinetics (including biodistribution, biodegradation, retention, excretion, blood circulation) are also drawing increasing attention because of their clinical application prospects. Herein, we review the most recent research applications about MSNs.

Keywords: Nanoparticles, Mesoporous silica nanoparticles, Cancer, Nanocarriers.