EFFECT OF HYDRO-ALCOHOLIC POLY HERBAL FORMULATION ON LIPID PROFILES WITH ATHEROGENIC DIET FED ANIMAL MODEL OF OBESITY IN WISTAR RATS

Shokouh Hajighasemi Dastjerdi, Muralidhar S. Talkad* and Anusha Umesh Shetty

ABSTRACT

Present study planned on anti-obesity in response to an atherogenic diet and to estimate the effect of Cyperus Rotundus Linn, Terminalia Arjuna & Cinnamomum Zeylanicum Nees, on serum lipid profiles, renal, hepatic function analysis in wistar rats. Obesity associated with Cardio vascular abnormalities is rapidly increasing throughout the world. Atherogenic or high fat diets were known to induce cardiovascular diseases, and several active compounds were tested to protect/prevent the risk of cardiovascular diseases. Obesity was induced by feeding rats with an atherogenic diet over a period of 60 days. Animals were divided into 6 groups, control, atherogenic diet, and 3 dose levels of hot infusion extract of herbal formulations of the hydro-alcoholic extract of herbal formulation containing Cyperous rotundus, Terminalia arjuna and Cinnamomum zeylanicum was administered orally in dose of 480mg/kg, p.o (high dose), 360mg/kg p.o (mid dose), 120mg/kg p.o (low dose) was administered daily for a treated group over a period of 60 days. Body weight, locomotor activity, organ and fat pad weights, lipid profile and renal function (Urea, Uric acid, Creatinine) ALT, AST activities were analyzed. Since the treatment with Cyperus rotundus poly herbal formulation significantly normalized the lipid profile. Plasma Adiponectin, Serum ALT, AST, urea, uric acid, and creatinine. Atherogenic diet induced obesity associated with a disturbed lipid profile, renal and liver implications for the progress of obesity related problems were examined, followed by the treatment with Cyperus rotundus poly herbal formulation improved obesity and its associated metabolic problems in different levels.

Keywords: Cyperus rotundus poly herbal formulation, Atherogenic diet, Lipid Profile, Renal Profile, Anti-obesity.