FORMULATION OF LOSARTAN AND HYDROCHLOROTHIAZIDE ORODISPERSIBLE TABLETS FOR IMMEDIATE ONSET OF ACTION BY USING SUPER DISINTEGRANTS

R. Raviteja, B. Ramu* and Dr. Bigala Rajkamal

ABSTRACT

The objective of this research was to formulate an immediate release tablets containing combination of Losartan and Hydrochloro thaizide for rapid action , by using a suitable binders and super-disintegrants.Faster disintegration of the tablet administrated orally minimizes absorption time and improves its bioavailability in less time. The main aim of IR technology is to achieve improved bioavailability, rapid onset of action, chemical stability and patient convenience and compliance. The tablets were prepared by direct compression and FTIR studies indicates that there were no incompatibility between the drugs losartan ,hydrochlorthiazide and formulation excipients.among the different formulations F7 was found to be optimed formulae which faster rate of drug release with increased bioavailability thus combination of losartan and hydrochlorthiazide were effectively formulated.

Keywords: losartan, hydrochlorthiazide, FTIR, superdisintegrants.