EVALUATION OF THE ANTI-INFLAMMATORY ACTIVITY OF MANGIFERIN ON CARRAGEENAN-INDUCED INFLAMMATION

Amit Mehra, Dr. Neelesh Kumar Dwivedi and Vijendra Trivedi*

ABSTRACT

Inflammation is a complex physiological response that plays a crucial role in the body's defense mechanisms but can also contribute to various pathological conditions when dysregulated. Mangiferin, a natural polyphenolic compound found in mango leaves and other plants, has shown promising anti-inflammatory properties in vitro and in some animal models. In this study, we aimed to evaluate the anti-inflammatory activity of mangiferin using a carrageenan-induced inflammation model in rats. Animals were divided into different treatment groups, including a control group, a positive control group receiving diclofenac, and experimental groups receiving varying doses of mangiferin. Paw edema and pain response were measured at different time points following carrageenan injection. Blood samples were collected for biochemical analysis of inflammatory markers. Our study design and methodology follow established protocols for evaluating anti-inflammatory agents in animal models. The findings from this study will contribute to our understanding of mangiferin's potential as a therapeutic agent for inflammatory disorders.

Keywords: Mangiferin, inflammation, carrageenan, anti-inflammatory activity, rat model.