INTRA NASAL DRUG DELIVARY SYSTEM: SCOPE, METHODS AND APPLICATIONS

Raikanapata Swetha* and Induru Jagadeesh

ABSTRACT

Nasal drug delivery has garnered attention from the scientific community because it may be investigated as a substitute delivery method for vaccines and biomolecules including proteins, peptides, and non-peptide medicines. In Ayurvedic medical system, intranasal therapy is a recognized mode of treatment. Medications that are unstable when administered orally can benefit from being administered via the nasal route because they are digested by first pass action in the liver or extensively degraded in the GIT. A good long-term therapeutic option is the nasal route, which is also an alternative to parenteral therapy. Because of its high vascularization and high permeability, the nasal mucosa allows for quick absorption and activity. Since the medication enters the bloodstream immediately through the nasal route, it is a non-invasive, often utilized local treatment method that can also be employed for systemic therapy. Small chemicals are better absorbed through the nasal route than large molecules, which can be enhanced by absorption promoters. This article provides an overview of intranasal medication delivery, covering its numerous features such as preparation procedures, evaluation techniques, efforts to improve bioavailability, and ingredients used to improve nasal absorption.

Keywords: Intra nasal drug delivery, vaccine delivery, polymers, penetration enhancer, absorption, bioavailability.