SYNTHESIS AND BIOLOGICAL ACTIVITY STUDIES OF 1-(2-(2-CHLOROPHENYL)-2-(6,7-DIHYDROTHIENO[3,2-c] PYRIDIN-5(4H)-YL) ETHYL) 5-METHYL-1H-1,2,3 TRIAZOLE-4-CARBOXYLIC ACID DERIVATIVES

Joga Sree Ram Babu*, K. Sudhakar Babu, T. Ravisankar and J. Latha

ABSTRACT

During the course of our investigation in the field of carboxylic acid antithrombotic agents, we have indentified and synthesized 1-(2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid (6a-6p) ,a carboxylic acid derivatives with good in vivo activity. These findings prompted us to prepare new derivatives 1-(2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid (6a-6p), in the hope of increasing activity and better understanding the influence of ester and amides.

Keywords: Antithrombotic activity, methylacetoacetate, thienopyridine, 1,2,3 triazoles, platelet aggregation.