FORMULATION AND EVALUATION OF MUCOADHESVIE BUCCAL TABLETS OF DONEPEZIL HYDROCHLORIDE FOR ALZHEIMER'S DISEASE

T. Usha Rani*, G. Tulja Rani, Shaik Naziya Fathima, Thalla Navya and Vallap Navya

ABSTRACT

This project is aim to formulate and characterize mucoadhesive buccal tablets of Donepezil, utilizing different proportions of three polymers carbopol 934, hydroxypropyl methylcellulose, and sodium carboxymethylcellulose. Eight batches of buccoadhesive Donepezil were prepared by the direct compression method. The compressed tablets were then evaluated for physicochemical parameters such as hardness, thickness, weight variation, drug content, friability, swelling index, surface pH, and ex vivo mucoadhesion. In vitro dissolution test was conduct for 12 hr according to Indian Pharmacopeia 2018, using the rotating paddle method in phosphate buffer of pH 7.4.

Keywords: Donepezil Hydrochloride, Mucoadhesive, Alzheimer’s disease, Buccal tablets, Polymers.