THE ROLE OF INFILTRATION BY LANGERHANS CELLS IN THE ASSESSMENT OF MALIGNANT LARYNX TUMERS PROGNOSIS

Ali Muhammad*, Mostafa Ibrahim and Ali Daoud

ABSTRACT

Background: Larynx cancer is a major challenge in ENT practice, so it requires deeper understanding, especially prognosis. Pathology in some studies on larynx cancer showed Langerhans cells infiltration in tumer stroma in some patients, which questions their role in prognosis assessment in these patients. Objective: To study the relation between langerhans cells infiltration on one side, and the malignant larynx tumers prognosis and other prognostic factors on the other side. Patients and Methods: A retrospective cohort study included patients whom biopsies from larynx tumers showed malignancy, and they had Laryngectomy in Tishreen University hospital between 2017 and 2020. Results: out of 21 cases, 16 were males (76.2%), 5 were females (23.8%), ages were between 41 and 76 years, age was converted to three groups, first from 41 to 50 years (23.8%), the second group from 51 to 60 years (28.6%), and the third group were above 60 years (47.6%), out of all cases 16 were smokers (76.2%), 4 were alcoholic (19%), Lymph node metastasis in 8 patients (38.1%), using s-100 immunostaining and morphology, minimum Langerhans infiltration was seen in 8 patients (38.1%), intermediate infiltration in 8 patients (38.1%), important infiltration in 3 patients (14.3%), and no infiltration in 2 (9.5%), and using CD1a immunostaining minimum infiltration was seen in 11 patients (52.4%), intermediate infiltration in 6 (28.6%), important infiltration in 2 (9.5%) and no infiltration in w (9.5%). the study showed statically important relation between the infiltration by Langerhans cells and the prognosis using S-100 (P-value=0.007) and using CD1a (P-value=0.003). However, no relation was shown with other prognostic factors. Conclusion: The study showed that better prognosis correlated with higher degree of Langerhans cells infiltration which indicates an important role in expecting prognosis during the treatment of larynx malignant tumers.

Keywords: Larynx cancer, Langerhans cells, S-100, CD1a.