ANALYTICAL COMPARISON OF PAIN BEHAVIOUR MODELS STUDY USING STANDARD AND REFERENCE DRUG REGIMENS

Erigbali P. P.,* Joffa P. P. K., Kiridi E. G., Pughikumo D. T., Ekeocha J. and Bisong J.

ABSTRACT

Typically, pain it is triggered by noxious stimuli and transmitted via specialized neural networks to
the central nervous system (CNS), where it is interpreted as such. Various animal experiment
models are developed to investigate pain phenomenon; and this study aimed to analytically consider
two models of pain behaviour studies in exploring for analgesic potential of reference regimens –
2,5-bis[(4-methoxyphenyl)methylidene]cyclopentan-1-one (D7) and 2,5-diethylidenecyclopentan-1-one (D8);
while using tramadol as standard control, with distilled water as normal control. Hot plate and water
bath experiment models of thermal pain induction in randomly selected and grouped mice were
implored to investigate effects of D7 and D8 on pain threshold. The results present both models
tallying in their independent assessments, while D7 expressed significant (P<0.0001) benefit in
analgesic potential.

Keywords: Pain, Experiment models, dibenzylidene compounds, tramadol, threshold.