PROTECTIVE EFFECTS OF ICARIIN ON CARDIOVASCULAR DISEASES – A REVIEW

Shabrina Zahratun Nisa, Adella Marsyanti, Aulia Nursyifa, Dhea Ananda, Diana Karlina,
Dini Hakiki, Fitrah Nur Fitriani, Lutvia Ramadhina, Muhammad Rizki Aditya, Nihal Shahifah,
Putri Fitriyah Husnul Khotimah, Rifky Syarif, Ristin Prasmawati, Rizma Septia Wahyuningsih,
Tarradiva Rosita Fitri, and Maulana Yusuf Alkandahri*

ABSTRACT

When the function of the heart and blood vessels is obstructed, cardiovascular disease is the resulting condition. Researchers have identified Icariin, a bioactive flavonoid compound from the genus Epimedium, as having a protective effect against a range of cardiovascular diseases. As a prenylated flavonol glycoside, this substance is classified. It is a 3,7-O-diglucoside 8-prenyl derivative of kaempferol. At present, Icariin has been the subject of numerous scientific investigations that have established its potential as a treatment for a wide range of cardiovascular ailments, including atherosclerosis, hypertension, stroke, heart attack, arrhythmia, heart failure, and hyperlipidemia. The protective potential of Icariin against a variety of cardiovascular diseases will therefore be the subject of this review article.

Keywords: Icariin, Atherosclerosis, Hypertension, Stroke, Heart attack, Arrhythmia, Heart failure, Hyperlipidemia.