A COMPREHENSIVE REVIEW: MUCOADESIVE LIPOSOMAL DRUG DELIVERY SYSTEM

Harshitha K. L.*, Mohammad Ali and Parthiban S.

ABSTRACT

Mucoadhesion is the term used to describe the adhesion between two materials, at least one of which is a mucosal surface. In the past few decades, mucosal drug delivery has been receiving a lot of attention. Mucoadhesive dosage forms allow for extended retention at the site of application as well as a controlled rate of drug release to achieve better therapeutic outcomes. Liposomes have been considered promising and versatile drug vesicles. Now a days, the preparation of mucoadhesive liposomal drug delivery system, it is able to improve the bioavailability of poorly absorbed oral drugs by prolonging their gastric and intestinal residence time, through facilitating the intimate contact of the delivery system with the absorption membrane. Liposomes are simple microscopic vesicles in which an aqueous volume is entirely enclosed by a membrane compose of a lipid moiety and are well known to alter the bio-distribution of entrapped substances by protecting the enclosed materials. Therefore, the preparation of mucoadhesion has attracted a great ideal of attention in the many pharmaceutics sectors. The mucoadhesive drug delivery system has many benefits that make it an innovative method for the local and systemic administration of various medications.

Keywords: Mucoadhesion, Liposomes, Membrane, Drug Delivery.