AN INSIGHT: MUCOAD H ESIVE BUCCAL DRUG DELIVERY SYSTEM

Chethan M.*, Mohammad Ali and Parthiban S.

ABSTRACT

The adhesion between two materials, at least one of which is a mucosal surface, is commonly referred to as mucoadhesion. Mucosal drug delivery has been receiving a lot of attention in the last few decades. Mucoadhesive dosage forms offer a controlled rate of drug release for better therapeutic outcomes by allowing for extended retention at the site of application. When dosage forms are applied to mucosal surfaces, they may help medication molecules that are not well suited for oral administration, like those that experience prolonged first-pass metabolism or acid breakdown. A dosage form's capacity to adhere to mucosal tissue depends on several factors, such as the composition of the mucosal tissue and the physicochemical characteristics of the polymeric formulation. An overview of the numerous aspects of mucoadhesion, mucoadhesive materials, factors influencing mucoadhesion, methods of evaluation, and, lastly, buccal mucoadhesive drug delivery systems are the objectives of this review article.

Keywords: Mucoadhesion, Buccal route, Mucosal surfaces, Polymer.