IN - VIVO STUDY ON INTERACTION OF KETOTIFEN FUMERATE WITH DI - CLOFENAC - NA ALONG WITH THEIR IR STUDIES

Md. Khalequeuzzaman, Md. Mominur Rahman, Mst. Rozina Parul*, Mohammed Aktar Sayeed,
Md. Nazmul Hasan

ABSTRACT

This is very much important than any other time or ever to know about the medicines we take. If we take several different medicines, suffering from various types of diseases, consult more than one doctor or have certain health conditions, we and our doctors must be aware of all the medicines we take to avoid potential problems, such as drug interactions. The study of Drug interaction between various drugs has been conducted for many years and successful results have also been established. In the continuation of the study of drug interaction we have studied the in vivo interaction between the Kitotifen Fumerate and Di-Clofenac Na along with their IR studies. In-vivo study showed decreased in the plasma concentration of free Ketotifen Fumarate when given concurrently with Di- Clofenac Na which may be due to the drug interaction. IR study confirmed that there is an interaction between Ketotifen Fumarate and Diclofenac Na with the presence of extra peaks in their combination (aqueous & chloroform extract) forms as compared to that of their pure forms. So, we can say that if both ketotifen fumerate with Di-Clofenac administer concurrently, mild complex can be formed after reaction which can ultimately reduce the pharmacological activities of both combinations of drugs.

Keywords: Kitotifen fumerate, Di-Clofenac Na, pharmacological activities & drug interactions.