FORMULATION AND EVALUATION OF NIFEDIPINE FAST DISINTEGRATING SUBLINGUAL TABLETS USING SUBLIMATION METHOD

P. Venkata Anudeep*, Y. Prapurnachandra, S. K. Ameer, S. Supraja, P. Bhavana, K. Viswa Roopa and T. Lavanya

ABSTRACT

Nifedipine, a commonly prescribed calcium channel blocker, is essential for managing hypertension and angina, yet its rapid release in traditional formulations poses challenges. This study explores a novel approach, utilizing sublimation technique, to formulate immediate-release Nifedipine tablets using direct compression method. The study systematically formulates Nifedipine tablets with varying concentrations of Croscarmellose sodium(CS), starch, and microcrystalline cellulose (MCC), meticulously optimizing disintegration and dissolution kinetics. The resulting tablets demonstrate uniformity in weight and drug content, aligning seamlessly with pharmaceutical standards. Additionally, FTIR analysis validates the compatibility between the drug and polymer, without any undesirable chemical interactions. Overall, this study unveils a promising avenue for enhancing Nifedipine therapy for hypertension and angina through the development of immediate-release tablets. Such optimized formulations hold the potential to significantly improve treatment outcomes for patients.

Keywords: Nifedipine, FTIR analysis, Croscarmellose sodium, microcrystalline cellulose.