EXPLORATION OF TRIGONELLA FOENUM-GRAECUM EXTRACT: CHEMICAL SCREENING, ANTI-WRINKLE ACTIVITIES, AND THERAPEUTIC POTENTIAL IN SKINCARE AND SUPPLEMENT

Supachai Chumchuen*, Somboon Tiranupan and Julalak Kantanalit Yoskrai Sridhanasakulchai

ABSTRACT

This study investigates the chemical screening and anti-wrinkle activities of Trigonella foenum-graecum extract. Chemical screening revealed significant yields of diosgenin, supported by Thin Layer Chromatography (TLC) analysis showing aligned Rf values with a standard reference compound. The extract exhibited MMP-1 and MMP-2 IC50 values of 34.87 ± 1.29 μg/mL and 22.11 ± 2.98 μg/mL, respectively, while gallic acid demonstrated lower IC50 values, suggesting superior anti-wrinkle properties. These findings highlight Trigonella foenum-graecum as a potential source of bioactive compounds with therapeutic implications for skincare. Further research is warranted to explore the extract's full chemical composition and pharmacological potential, paving the way for the development of novel anti-wrinkle formulations and pharmaceutical applications.

Keywords: Trigonella foenum-graecum, Anti-collagenase, Anti-elastase, Diosgenin.