TRANSETHOSOMES: INNOVATIVE VESICULAR TOOL FOR TOPICAL DRUG DELIVERY

Ajisha V.*, Viresh K. Chandur, A. R. Shabaraya

ABSTRACT

The increasing demand for novel medication delivery methods has prompted a great deal of research to overcome the drawbacks of conventional dosage forms. Drug delivery occurs via liposomes however, these particles usually stay in the upper stratum corneum of the skin, preventing drug penetration. Ultra-deformable vesicles (UDV) are a type of new lipid vesicles that have been designed to enhance medication delivery. Transethosomes have drawn interest in this context as a potential remedy because they provide unique benefits above conventional formulations. Transethosomes reduce poor bioavailability, organ toxicity, first-pass metabolism, and plasma variations. An extensive examination of transethosomes is given in this review and how formulation elements affect the agent characteristics and efficient targeting. This article explores the properties of production and assessment used to guarantee effective drug delivery. By this review substantial contribution by analyzing the different transethosome administration routes, such as transdermal, transvaginal, pulmonary, and ocular delivery. Overall, this work highlights transethosome’s tremendous promise as a practical drug delivery technique that can overcome the drawbacks of traditional drug delivery methods.

Keywords: transethosomes, conventional drug delivery, liposomes, ethosomes.