AN OVERVIEW OF LIQUISOLID TECHNOLOGY TO ENHANCE DRUG DISSOLUTION

Nashida A.* and Mamatha G. T.

ABSTRACT

Dissolution of drug and its release from the dosage form have basic impact on bioavailability. The solubility of a medication determines its bioavailability. As new medications are developed, solubility becomes a significant concern for the pharmaceutical industries. About 40% of recently developed medications fit into the poor water soluble or water insoluble classifications. Generally speaking, weakly water-soluble medications have an aqueous solubility of less than 100 μg/ml. There are numerous ways to improve the solubility of poorly soluble medications, and one particularly effective method is the use of liquisolid compacts. A unique idea for a drug delivery system (NDDS) that can speed up the rate at which water-insoluble medications dissolve is the Liquisolid compact system. The basis of this liquisolid method is the dissolution of the insoluble drug in a non-volatile solvent, followed by the mixing of drug-loaded solutions with suitable carriers and coating materials to produce powders that flow and compress into acceptable levels. These free flowing powders are compressed to make tablets or filled in capsules.

Keywords: Liquisolid technology, Bioavailability enhancement, Carrier material, Coating material.