FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLET OF TOPIRAMATE

Prof. Perane Kartiki Sambhaji*, Waghmare Priyanka Thomas, Walke Utkarsha Anil and Zuge Saurabh Govardhan

ABSTRACT

This study aimed to formulate and evaluate mouth dissolving tablets of topiramate, an anti-epileptic drug, using wet granulation method. Six batches (F1-F6) were prepared with varying super disintegrants (Crospovidone and Sodium Starch Glycolate) and binders (Methyl Cellulose and Starch). The granules were evaluated for Angle of Repose, Tapped Density, Bulk Density, Hauser Ratio, and Carr’s Index. Tablet evaluations included Hardness Test, Friability Test, Dissolution Test, Content Uniformity, Disintegration Test, Thickness, Weight Variation, Size, and Shape. Disintegration times ranged from 25 to 46 seconds, and in-vitro dissolution studies showed percentage release ranging from 67.23% to 95.84%. The tablets aimed to improve patient compliance, rapidly disintegrate, and release drug in saliva, obviate water requirement, cater to paediatric and geriatric patients, avoid first-pass metabolism, ensure high bioavailability, and achieve rapid onset of action.

Keywords: Mouth Dissolving Tablet, Anti-Epileptic,Anti-Convulsant,