A COMPREHENSIVE REVIEW ON ETHNOBOTANY AND PHARMACOLOGICAL ACTIVITIES OF SIMAROUBA GLAUCA
Drisya M. K.*, Revathi M., Barsha S. Babu, Hitha Ashok, Jannath Sherin, Nivethya Jayan
ABSTRACT
Simarouba glauca (S. glauca) commonly known as ‘Laxmitaru’ or ‘Paradise tree’ belongs to the Family Simaroubaceae, is a medicinal plant that is rich in bioactive chemicals with a variety of pharmacological effects. This review aims to provide an overview of the chemical constituents that is present in the crude drug of Simarouba glauca, with an emphasis on their pharmacological properties. Simarouba's bark and leaf extract exerts various pharmacological effects such as antiamoebic activity, antifungal properties, antimalarial activity, antiulcer activity, hepato protective property, anticancer effects and reduce patchy skin pigmentation. The active phytoconstituent responsible for the pharmacological actions of Simarouba glauca includes glaucarubin, quassinoids, ailanthinone, benzoquinone, holacanthone, melianone, simaroubidin, simarolide, simarubin, simarubolide, sistosterol. Further exploration of its bioactive constituents and therapeutic applications holds promise for addressing a wide range of health challenges.
Keywords: Simarouba glauca, Laxmitaru, quassinoids, Pharmacological action.
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