DENTIN BIOMODIFIERS USED IN DENTISTRY

Dr. Shilpi Kumari*, Dr. Naveen Manuja, Dr. Seema Chaudhary, Dr. Somy Agarwal

ABSTRACT

The vast majority of aesthetic dental restorations are performed using resin composites. Ensuring a durable bond between the tooth surface and the adhesive resin is crucial for the long-term success of composite restorations in clinical practice. While adhesive systems have made significant advancements, the bonded interface continues to be the least robust aspect of resin-based restorations. The primary reason for this is the degradation of exposed collagen at the base of the hybrid layer, which results in a decline in the resin-dentin bond. Researchers are currently exploring different dentin biomodifiers to mitigate the enzymatic breakdown of collagen and enhance their mechanical durability. Dentin biomodification utilizes matrix metalloproteinase inhibitors and collagen cross-linkers on acid-conditioned dentin. While the research is still in its early stages, dentin biomodification shows promise as a method to enhance the stability of the resin-dentin bond. This paper provides a concise overview of various dentin biomodifying agents, their mechanisms of action, and their impact on enhancing the durability of the resin-dentin bond.

Keywords: Resin-dentin bond; Matrix metalloproteinase inhibitors; Collagen cross linkers; Bond durability.