REVIEW ON MICROSPONGE DRUG DELIVERY SYSTEM: CURRENT STATUS AND THEIR FUTURE PROSPECTS

Mamatha G. T., Akshay Bandhukar H. V.*, Parthiban S. and Jagadeesh D. K.

ABSTRACT

Microsponges are the tiny sponge -like spherical particles with a large porous surface, particle size ranging from 5 to 300μm in size. Microsponges are designed to deliver the drug effectively at a comparatively lesser dose, enhancing the stability, modifying the drug release profile and minimizing the side effects. Preparation of the microsponges includes two techniques: Liquid–liquid suspension polymerization and Quasi-emulsion solvent diffusion method. Their characterization can be done in many ways like particle size determination, morphology and surface topography, scanning electron microscopy, Determination of loading efficiency, Determination of production yield, Determination of true density, determination of true density, compatibility study, resiliency, stability studies and safety studies. Present work focus on various application and future prospects of the microsponges.

Keywords: Microsponges, polymer, Liquid–liquid suspension polymerization, quasi-emulsion diffusion solvent method, porous structure.