SYNTHESIS AND BIOLOGICAL EVALUATION OF MORPHOLINE AND SALICYLAMIDE NUCLEUS BASED DERIVATIVES
Loganathan Velupillai, Prashant P Dixit, M.S. Shingare & D.V. Mane*
ABSTRACT
Morpholine backbone is essential in different pharmacologically active
synthetic compounds. Present work is synthesis of novel morpholine
and salicylamide nucleus based compounds such as 3-amino-2, 2-
dimethylpropyl 2-(2-(2-morpholinoethylcarbomyl)phenoxy)acetate and
their derivatives (6 L – 6 R). The compounds were synthesized in
multistep reaction with more efficient process. Starting materials are
commercially available and is also available from Sigma-Aldrich. The chemical structures of
the synthesized compounds were confirmed by means of 1HNMR and mass spectral data.
High yield and high purity indicates lack of side reaction and by product. The synthesized
compounds were then examined for their antibacterial and antifungal activities. Some of them
were found to possess good antibacterial and antifungal activity.
Keywords: Morpholine, Salicylamide, Salicylic acid, Antibacterial, Antifungal Activity.
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