NIPAH VIRUS: A COMPREHENSIVE REVIEW OF VIRAL GENOME, GLOBAL BURDEN OF DISEASE EPIDEMIOLOGY, ANTI-VIRAL, NANO-TECHNOLOGY, VACCINE TECHNOLOGIES AND ARTIFICIAL INTELLIGENCE AND SMALL INTERFERING RNA BASED ADVANCED THERAPEUTICS

Zahra Zahid Piracha*, Seneen Noor, Muhammad Afaq Khan, Hafiza Shanza Ambreen, Muhammad Raza, Manaal Amir Basra, Elyeen Noor, Muhammad Nouman Tariq, Syed Shayan Gilani, Bazaid Muhammad, Syeda Kaainaat Binte Waheed7 and Umar Saeed*

ABSTRACT

Nipah virus (NiV) is a zoonotic virus that may infect both humans and animals and may cause serious diseases. NiV can spread from one person to another by respiratory droplets or contact with bodily fluids that are contaminated. In Bangladesh, India, Malaysia, and Singapore, NiV epidemics have been observed. Over 100 people died in Malaysia during the first NiV outbreak, which happened in 1999. Since then, Bangladesh and India have experienced a number of minor NiV outbreaks. The NiV virus can be targeted by new antiviral medications made using nanotechnology, novel vaccinations can be created using artificial intelligence, as well as novel diagnostic tests for NiV infection. Small interfering RNAs can be utilised in treatments to suppress the NiV virus. The prevention and treatment of NiV infection could be greatly enhanced by these new technologies. To improve these technologies and introduce them into clinical practise, more study is necessary. Although the burden of NiV infection is still quite low worldwide, there is a real danger that the virus could spread widely. To reduce this danger, new tools for the diagnosis, treatment, and prevention of NiV infection must be developed. There is an urgent need for more research into NiV infection, and for the development of new technologies to prevent and treat the disease.

Keywords: Nipah Virus, Epidemiology, Prevalence, Global Burden of Disease, Artificial Intelligence, Anti-Viral, Small interfering RNA.