FORMULATION AND EVALUATION OF PARACETAMOL TABLET USING MCC AND PVP AS A COMBINATION BINDER

Prof. Bhawal Ganesh Shivaji*, Hurule Vaishnavi Vishnu, Guldagad Akshay Machhindra, Ghorpade Pratik Dattatray, Harishchandre Seema Nanasaheb and Ingale Neha Shivaji

ABSTRACT

The aim of present work was to utilize the combination binding property of MCC and PVP using paracetamol as model drug. Initially compatibility of both bindings was verified with the other excipients used. Thereafter, four batches were formulated using MCC and PVP as a binding agent in different proportions. A reference batch of MCC was also prepared to carry out the comparative study and to assess the binding study property of MCC and PVP when used in combination. Precompression and post Compression studies were performed for each formulation. The results obtained for all pre-compression and post compression parameters were found within acceptable range of pharmacopoeias. Test for powder like bulk density, tapped density, carr’s index, hausner ratio and angle of repose as pre compression study and test for tablet like tablet dimension, hardness, weight variation, friability, disintegration time, were conducted as post compression evaluation. On the basis of drug release behavior it can be summarized that release of all four batches under study was less than that of reference batch. Since the utilization of combination binders can be at low cost it may prove to be better binder over commercially used single binders. The formulation process involves the optimization of tablet compositions to achieve tablets with desirable characteristics such as mechanical strength, uniformity of drug content, and dissolution profile. Various concentrations of MCC and PVP are explored to determine their influence on tablet properties. Comparative studies are conducted between tablets formulated with MCC-PVP combination binder and those formulated with individual binders to assess the synergistic effect of the combination binder system. Overall, this study provides valuable insights into the formulation strategy employing MCC and PVP as a combination binder for paracetamol tablets, paving the way for the development of high-quality pharmaceutical dosage forms with improved therapeutic efficacy and patient outcomes.

Keywords: MCC- Microcrystalline cellulose, PVP- Polyvinylpyrrolidone.