FORMULATION AND EVALUATION OF BIFONAZOLE NANOEMULGEL FOR TOPICAL DELIVERY

K. Deekshitha* , Harsha V. C., Vineetha K. and A. R. Shabaraya

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ABSTRACT

Emulgels are emulsions, either of the oil-in-water or water in-oil type, which are gelled by mixing with a gelling
agent. This study is to investigate the potential of Nanoemulgel formulation to improve the controlled release of
Bifonazole (BIF). Bifonazole is an antifungal drug used to treat various fungal infections like Tenia pedis etc.
Nanoemulsion were formulated by highspeed homogenization technique by using oleic acid as oil, Tween 80 as
surfactant, Isopropyl Alcohol as co-surfactant. The resultant Nanoemulsion were characterized by Particle size,
Zetapotential, Drug content, In-vitro drug release. Best formulation F2 showed particle size of 33.37nm, Zeta
potential of -21.2mV and a maximum drug release of 79.17% in 7 hours. The best formulation F2 was choosen
based on the particle size and drug release, which is then incorporated to carbopol 934 gel for the proper feasibile
application to the skin. The prepared gel was evaluated for its parameters like Physical apearene, pH, drug content,
spreadablity, viscocity, Invitro diffusion studies and kinetic studies. Result revealed that the formulation F2 having
90.98% of drug content, cumulative drug release of 82.55% with a spreadability of 19.03. The results obtained
suggest that the Nanoemulgel could be an efficient carrier for topical application in the treatment of fungal
infection like Tinea pedis etc.

Keywords: Emulgel, Topical drug delivery, Emulsion based gel formulation and Evaluation.