EVALUATION OF HYPOGLYCEMIC POTENTIAL OF ADIANTUM CAUDATUM IN STREPTOZOTOCIN INDUCED DIABETIC RATS
Anil Kumar Jatav*, Dr. Nitin Jumnani, Amit Vashistha and Dr. Praveen Goyal
ABSTRACT
Objective: Leaves, Root and fruit of Adiantum caudatum (Pteridaceae) has been used in traditional health systems to treat diabetes and many more disorders in various country. However hypoglycemic potential of leaves of this valuable plant is not scientifically validated till date. The aim of present study is to evaluate hypoglycemic effect of ethanol extracts and solvent fractions of A. caudatum leaves. Methods: The ethanol extracts and solvent fractions in different dose concentration 150, 300, 600 mg/kg of A. caudatum leaves were evaluated for hypo-glycemic effect in single dose and multiple dose study for 21 days in streptozotocin induced diabetic rats. Results: The acute toxicity study of A. caudatum extract and fractions did not show mortality in the animals at the limit dose of 2000mg/kg during the observation period. The outcome of present study indicates that extract significantly decreases elevated level of blood glucose in dose dependant manner when compared to untreated diabetic rats. Conclusion: The observed result may be due to active principles present in extract and fractions. ethanolic extracts and chloroform fractions of Adiantum caudatum (150, 300 & 600 mg/kg b.w) were tested, in which 300 and 600 mg/kg dose have shown significant (P<0.01) anti-diabetic activity compared to standard drug. The claimed traditional use as anti-diabetic has scientific back ground.
Keywords: Adiantum caudatum, hypo-glycemic, streptozotocin, ethanol.
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