REVIEW ON FAST DISSOLVING SUBLINGUAL FILMS

Lavith Kumar H.*, Bhavya Shree T. and Krishnananda Kamath K.

ABSTRACT

Fast dissolving drug delivery system dissolves in saliva without the need for water and disintegrates quickly. Fast Dissolving Drug Delivery Systems offer a significant advantage over conventional dosage forms. It produces immediate systemic effect by enabling the drug absorbed quickly or directly through mucosal lining of the mouth beneath the tongue. Fast dissolving sublingual film can be formulated using different approaches like solvent casting method, semisolid casting method, hot melt extrusion method, solid dispersion extrusion method, rolling method. The sublingual area of the oral cavity is more permeable than the buccal (cheek) area, which in turn is more permeable than the palatal (roof of the mouth) area. This review highlights on different approaches for sublingual dosage forms, factor affecting the sublingual absorption, advantages and disadvantages, various evaluation parameters for the sublingual films.

Keywords: Fast dissolving sublingual film, Solvent casting method, hot melt extrusion, rolling method.