COMPREHENSIVE STUDIES OF ANALYTICAL METHODS FOR DROSPIRENONE AND ETHINYL ESTRADIOL
Kavana B. B.*, Manju S. V., Chandanam Sreedhar, Harsha K. Tripathy, T. Srinivasa Rao and Venkatesan R
ABSTRACT
Oral contraceptive (OC) pills contain Estrogen and progestin that are synthetic analogs of natural hormones. These synthetic hormones affect the hypothalamus-pituitary-gonadal axis of the female reproductive system. There are many types of contraceptives; most of the OC pills prevent pregnancy by inhibiting ovulation. Drospirenone is a novel progestin with anti-mineralocorticoid and anti-androgenic properties, while ethinylestradiol is a synthetic estragon. The synergistic effects of these two hormones make this combination an effective and versatile option for various women's health applications. This article aims to provide comprehensive details regarding drospirenone and ethinylestradiol, including information on many contraceptive pills along with its concentration, mechanism of action, side effects and various analytical techniques such as RP HPLC, HPLC, UV, LC and HPTLC. The article will also elucidate different analytical methods used in recent studies.
Keywords: Drospirenone, Ethinyl estradiol, HPLC, UV, RP-HPLC and HPTLC.
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