A REVIEW OF THE ANTIINFLAMMATORY AND ANALGESIC CONSTITUENTS OF THE FAMILY ANNONACEAE

Enema O. J.*, Umoh U. F., Johnny I. I. and Igwe M. N.

ABSTRACT

Inflammatory and pain-related disorders constitute a significant global health burden, often treated with synthetic drugs that can elicit adverse side effects. The Annonaceae family, a botanical group traditionally employed in various cultures for its therapeutic properties, has shown potential as a source of natural anti-inflammatory and analgesic agents. This review paper aims to critically evaluate the scientific literature on the anti-inflammatory and analgesic properties of the Annonaceae family to consolidate current knowledge, highlight research gaps, and suggest directions for future research. The methodology of this review involved a systematic search of databases for studies on Annonaceae species, focusing on their reported uses in traditional medicine and the scientific validation of these uses. Studies were included if they provided data on the phytochemical content, pharmacological activities, and mechanisms of action related to anti-inflammatory and analgesic effects. The results indicate that several species within the Annonaceae family contain bioactive compounds, such as acetogenins, alkaloids, and essential oils, which exhibit significant anti-inflammatory and analgesic activities. Some notable examples include Annona muricata, Annona senegalensis, and Annona squamosa, which have been documented for their potential in treating a variety of inflammatory and painful conditions. Pharmacological screenings have provided evidence supporting the traditional uses of these plants, demonstrating their effectiveness in reducing inflammation and pain in both in vivo and in vitro studies. The Annonaceae family shows great promise as a natural source of anti-inflammatory and analgesic compounds. However, more rigorous scientific studies, including clinical trials, are essential to fully understand the therapeutic potential and safety profile of these plant species. This review underscores the need for further exploration of Annonaceae species, to develop safer, natural alternatives to synthetic drugs for the management of pain and inflammation.

Keywords: Annonaceae, anti-inflammatory, chemical constituents, pharmacological activities.