SYNTHESIS OF N-SUBSTITUTED NAPTHOFURAN CARBOXAMIDES DERIVATIVES AS POTENTIAL ANTIMICROBIAL AGENTS

Sapna Rajput*, Kratika Daniel and Sachin Kumar Jain

ABSTRACT

Prompted by the varied biological activities of carboxamides and napthofurans, a series of N-substituted napthofuran carboxamides (NFC1-5) derivatives were prepared. The starting material naphthol was treated with paraformaldehyde, triethyl amine, magnesium chloride and methyl cyanide to form 1-hydroxy-2-naphthaldehyde. Further reaction of corresponding naphthaldehyde with ethyl bromo acetate form Ethyl Naphtho[1,2-b]furan-2-carboxylate which undergo hydrolysis to prepare naphofuroic acids Which on treated with aromatic primary amines to convert into N-substituted napthofuran carboxamides. The structures of these compounds were confirmed by IR, NMR, Mass and elemental analysis. The newly synthesized compounds were evaluated for antibacterial and antifungal activity. The results show that compound NFC1-5 exhibited moderate to good antibacterial and antifungal activity.

Keywords: The starting material naphthol was treated with paraformaldehyde, triethyl amine, magnesium chloride and methyl cyanide to form 1-hydroxy-2-naphthaldehyde.