DEVELOPMENT AND VALIDATION OF THE RP- HPLC METHOD USING HYDROTROPIC SOLVENT TECHNOLOGY FOR THE ESTIMATION OF EMPAGLIFLOZIN IN BULK DRUG AND DOSAGE FORM

Nagare Madhuri B.* and Waghmare Sonali A.

ABSTRACT

By using hydrotropic solvents as the mobile phase, the bulk of the organic solvent in the analysis may be decreased. An RP-HPLC technique for estimating the amount of empagliflozin in tablets was developed. Excellent drug recovery percentage was attained, and the suggested approach was judged to be exact, reliable, innovative, and accurate. The ICH guidelines' constraints were met by the linearity, accuracy, range, and robustness. As a result, the process was discovered to be quick, innovative, straightforward, accurate, precise, economical, and repeatable.

Keywords: Hydrotropy, Empagliflozin, Validation ICH guideline.