THERAPEUTIC STRATEGIES FOR COVID-19: A REVIEW OF CURRENT RESEARCH AND CLINICAL TRIALS

Apollos Ebi-erefa, Hyellavala Joseph Fomnya*, Blessing Benjamin Awu, Garleya Bilbonga and Inalegwu Adonyikwu

ABSTRACT

The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has prompted global health emergencies and a swift response from the scientific community. This review summarizes the current state of knowledge on the mechanisms of action and efficacy of several key drugs, including hydroxychloroquine, azithromycin, remdesivir, umifenovir, and others. The study highlights the potential benefits and limitations of these treatments, including their effects on viral replication, inflammation, and immune response. Additionally, it discusses the role of corticosteroids and convalescent plasma in managing severe cases of COVID-19. Epidemiological data reveal the rapid spread and significant morbidity and mortality associated with COVID-19. The virus primarily targets the respiratory system, but its impact extends to multiple organ systems, leading to diverse clinical manifestations. Research highlights the critical need for effective antiviral therapies and vaccines to combat the pandemic. Continuous surveillance, comprehensive clinical studies, and the development of robust healthcare strategies are essential to mitigate the virus's impact. This review emphasizes the urgent need for global collaboration in research and healthcare to manage and eventually overcome COVID-19.

Keywords: COVID-19, Antiviral therapy, Immune response, Convalescence plasma.