FORMULATION AND EVALUATION OF KETOROLAC TROMETHAMINE SUSTAINED RELEASE MATRIX TABLET USING HIBISCUS ROSA–SINENSIS LEAVES MUCILAGE AND HPMC E50

Elakkiyamani* and S. Merina Josephine

ABSTRACT

The present study was aimed to evaluate the Sustained release matrix tablet Keterolac Tromethamine was. formulated by natural and synthetic polymers to check the percentage drug release of drug in particular time limit . Ketorolac Tromethamine is a Non Steroidal Anti- inflammatory drug. KT is used for the short-term treatment of moderate to severe pain in adults. It is usually used before or after medical procedures or after surgery. Reducing pain helps you recover more comfortably so that you can return to your normal daily activities. In this synthetic polymer is an HPMC E50 and Natural polymer is Hibiscus rosa-sinensis in this research. In this study observed that by increasing the concentration of polymers had retarding effect on the drug release from the polymer matrices. The matrix tablet consist of F1, F2, F3, F4, F5, F6 six types of formulation was prepared by direct compression method. The prepared tablets were characterized for pre compression, post compression, in- vitro percentage release studies by using a different ratio’s of polymers on release characterestics. The results of pre and post compression parameters were found within the standard pharmacopeial limits Formulation containing 60% of Hibicus mucilage is able to sustain 50% of drug over a period of 8 hrs part.

Keywords: Keterolac Tromethamine, Hibiscus rosa-sinensis, HPMC E50.