EXPLORING THE ANTI-UROLITHIC AND ANTIOXIDANT PROPERTIES OF COCCINEA LEAVES: A COMPREHENSIVE EVALUATION

Asif Rasheed*, Saniya Ruqsar, Safura Tazeen, Farheen Tarannum and Rashed Bin Mahsen Al Hamumi

ABSTRACT

Exploiting the leaves of Ixora coccinea Phytochemical, Pharmacological aspects with special emphasis on anti urolithiatic activity. The phytochemical screening result shows Alkaloids, Carbohydrates, Proteins and aminoacids, Tannins and phenolic compounds, Phytosterols, Flavanoids, Saponins, etc. In the present study, the urine amount augmented in the treated group’s animals than that of the control and it abridged in the untreated lithiatic animals when comparing to the standard and urinal concentration of an assortment of ions investigated varied drastically. The antioxidant activity of the Ethanolic extract was estimated by five methods. DPPH radical scavenging activity, reducing power determination, scavenging of hydrogen peroxide, Assay of nitric oxide scavenging activity and compared with different standards like Ascorbic acid, Quercetine and Epicatechine. Ixora coccinea are having antioxidant activity. It was evaluated by five methods. In the Hydrogen peroxide scavenging activity method, the IC50 values are calculated and compared with the standard Ascorbic acid, it depicts 140 μg of Ixora coccinea of is equivalent to that of 12.5 μg of ascorbic acid. In the present study, Ixora coccinea are having good antioxidant and antiurolithiatic activity, it was proved obviously in this juncture. Meticulous percevings of the patho-physiology of illness and method of action of these herbal medicines have great importance in improvement of effective and safe antiurolithiatic agent. The antioxidant action was calculated as free radical scavenging activity technique, Nitric oxide scavenging, DPPH method, Reducing control determination technique, Hydrogen peroxide method. All the methods depict good response due to thepresence of phenolic compounds and flavonoids in three species. The herbal drugs exert their urolithiatic consequence by varying the ionic content of urine lessening the ca+ and oxalate ion strength or escalating magnesium and citrate excretion and also with diuretic activity. In this respect this information provides a fruitful area for scientific research by willing investigators. An attempt may be made to develop new herbal formulation to treat Kidney stone by Ixora coccinea plants. From this present study we can conclude by using this Ixora coccinea, we can go for herbal formulation development to treat Kidney stone.

Keywords: Anti-Urolithic, Antioxidant, Coccinea Leaves, Phyto chemical evoluation.