EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

ADVERSE EFFECTS OF SOME DRUGS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES

Kumar P.*, Chaturvedi S. C., Sharma A. and Rai G.

ABSTRACT

The study is aim to assess the patient knowledge with the help of knowledge assessment questionnaire (KAQ) about the disease and detects the ADRs. This study was designed to compare adverse effects on cardiovascular drugs. Adverse drug reaction (ADRs) is a major cause of mortality worldwide. The objective of the present study were a) to find out the prevalence of adverse drug reaction (ADRs) in the hospitalized patient by active surveillance, b) to study the profile of ADRs detected and probable factors contributing to the same. This was a cross sectional study conducted at super specialty hospital Sri aurobindo medical college, Indore and high tech super specialty Indore, for four month study. Total number of patients taken for study was 50 in number. From many criteria‟s which was included firstly on the basis of gender were 25 males and 25 females. The patients were in age group more than 50 year was 25 and 35-50 were 14. drug used for their co morbidities to find out ADRs in which maximum ADRs found in chronic rheumatoid heart diseases, for this diseases patient took in two combination mainly Digoxin with Clopidogrel(47.36%) and another were with atorvastatin, spironolactone and warfarin (47.30 % ADRs) which was maximum in compare to other diseases. Adverse drug reactions on particular body system were mostly observed on CNS (32.14%ADRs). Also, Patient on combination therapy (Digoxin, furosemide, and spironolactone) had significantly more complaints regarding side effects than other category of drugs. The results obtained in some of previous studies in which digoxin and furosemide were well tolerated. The side effect experienced by spironolactone was swelling, hypotension, and systolic dysfunction. According to Naranjo naranjo causality assessment scale applied to this study illustrates that the maximum possible and probable adverse drug reaction were shown on Furosemide as well as for Digoxin and Spironolactone.

Keywords: Adverse drug reaction, Pharmacovigilance, Prospective, observational, Cardiovascular.

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