FORMULATION DEVELOPMENT AND IN VITRO EVALUATION OF PREGABALIN IN SITU NASAL GEL

Mamatha Kola*, R. Nagaraju, Agniparthy Sudha Sree, G. Jhahnavi, Praneetha V., Mohammad Bakhatwar and Ch. Srilatha

ABSTRACT

The aim of the present study was to formulate and characterize mucoadhesive pregabalin in situ nasal gels for brain delivery. Pregabalin acts as an anti epileptic drug and is used in chronic pain, and other psychological disorders. Mucoadhesive nasal gels were prepared using combination of polymers like HPMC K4M, carbopol 934 and sodium alginate. A total of 5 gel bases were prepared and were characterized in terms of clarity, viscosity, gelation temperature, gelation time, muco adhesive strength, gel strength and in vitro permeation studies. The results showed that muco-adhesive strength and viscosity increases with increase in polymers concentration. In vitro drug permeation profiles showed that pregabaline in situ gel F1 provided a better controlled release of 68.89% than the other formulations and it exhibited better in-situ gelling properties, pH, gelling temperature, clarity, viscosity and gel strength. Mucoadhesive nasal gel of Pregabalin is a novel dosage form which delivers the drug directly via nasal cavity to brain through trigeminal neural pathways and provides controlled release of the drug.

Keywords: Novel dosage form, Pregabalin, Carbopol 934, HPMC, Sodium alginate, Mucoadhesive nasal gel.