NAVIGATING THE LANDSCAPE FOR INNOVATIONS IN SOLUBILITY ENHANCEMENT FOR NEXT-GENERATION THERAPEUTICS: A RECENT REVIEW

Simran Chaurasia*, Shivam Bhadauria, Tirath Choudhary and Mansi

ABSTRACT

The significance of solubility in pharmaceutical formulations cannot be overstated, as it profoundly shapes drug dissolution, absorption, and therapeutic efficacy. However, the limited solubility of numerous pharmaceutically active compounds poses a formidable obstacle in drug development, frequently resulting in suboptimal bioavailability and therapeutic outcomes. Addressing this challenge is paramount for fostering pharmaceutical innovation and fulfilling the medical needs of patients worldwide. This comprehensive review meticulously examines diverse strategies aimed at augmenting the solubility and bioavailability of poorly water-soluble drugs, with a special emphasis on their pivotal role in pharmaceutical research and development. Leveraging insights gleaned from a synthesis of scientific literature, this review provides an in-depth analysis of the contributions of nanotechnology, chemical methodologies, physical interventions, and miscellaneous techniques like particle size reduction, Hydrotropy, pH adjustment, Supercritical Fluid Process, Solid Dispersions, Inclusion Complexation, Lyophilization, Spray drying and many more to solubility enhancement. By elucidating the underlying mechanisms and practical applications of these methodologies, this review endeavors to furnish invaluable guidance to researchers and practitioners navigating the intricate landscape of drug development, with the ultimate goal of advancing patient care and therapeutic outcomes.

Keywords: solubility, dissolution, absorption, bioavailability, water-soluble drugs.