EVALUATION OF THE ANALGESIC ACTIVITY OF THE AQUEOUS EXTRACT OF THE TRUNK BARKS OF DETARIUM MICROCARPUM GUILL. AND PERR IN MUS MUSCULUS

Kouamé Yao Yves*, Kouakou Yeboué Koffi François and Dosso Mamadou

ABSTRACT

This study aims to scientifically prove the traditional use of Detarium microcarpum to relieve pain. Phytochemical screening revealed in the aqueous extract of Detarium microcarpum trunk barks, there are alkaloids, polyphenols, tannins, flavonoids, leucoanthocyanins, saponosides, polyterpenes and sterols. However, the study indicated an absence of quinones. The determination of trace elements revealed contents of zinc (7.94 ± 0.11 μg/g), potassium (15723.97 ± 0.68 μg/g), copper (38.42 ± 0.44 μg/g), magnesium (1001.14 ± 0.23 μg/g) and iron (49.84 ± 0.70 μg/g). The study of the acute oral toxicity of the aqueous extract of the trunk bark of Detarium microcarpum in Mus musculus revealed that the extract was not toxic up to a dose of 2000 mg/kg bw. The percentages of inhibition of the aqueous extract of the trunk bark of Detarium microcarpum at doses of 100 and 200 mg/kg bw were respectively 59.09 and 68.18% while the percentage of inhibition of EFFERALGAN 1000 mg at the dose of 150 mg/kg bw was 75.77 %. The analgesic effect of EFFERALGAN 1000 mg at a dose of 150 mg/kg bw was the same (p > 0.05) as that of the aqueous extract of the trunk bark of Detarium microcarpum at a dose of 200 mg/kg bw. However, the analgesic effect of EFFERALGAN 1000 mg at a dose of 150 mg/kg bw was significantly greater (p < 0.05) than that of the aqueous extract of the trunk bark of Detarium microcarpum at a dose of 100 mg/kg bw. kg pc.

Keywords: Detarium microcarpum, Analgesic, phytochemical screening, trace elements.