DRUG-INDUCED HORMONAL HAVOC: A CASE REPORT ON FLUCONAZOLE AND ADRENAL INSUFFICIENCY

Akshara K. R.*, Dr. Sara Kurien K., Dr. Jency Maria Koshy and Dr. Swetha Reba Mathew

ABSTRACT

Fluconazole is a widely used triazole antifungal agent which is available for oral or intravenous use. Studies have shown its activity against infections caused by various fungal species.[1] Long-term azole therapy is associated with hepatotoxicity and hormone-related effects, including gynecomastia, alopecia, decreased libido, oligospermia, azoospermia, impotence, hypokalemia, hyponatremia, etc.[2] Although rare, there have been case reports that describe an association between Fluconazole and adrenal dysfunction which is an important cause of morbidity and mortality in patients who are critically ill.[3] So here we present the case of a 39-year-old male who experienced adrenal insufficiency while on treatment with Fluconazole for the therapeutic management of candida albicans.

Keywords: Fluconazole, Adrenal insufficiency, Candida Albicans, Antifungals, Drug induced adrenal dysfunction.