FORMULATION AND EVALUATION OF ANTI INFLAMMATORY TRANSDERMAL PATCHES USING LEAF EXTRACTS OF ARISTOLOCHIA INDICA AND BOERHAVIA DIFFUSA

Sreelakshmi K. P.*, Delna M. S., Megha Balakrishnan K., Sandra P. D. and Arya A.

ABSTRACT

Indian birthwort or Aristolochia indica, is one of the most significant plants found throughout India and has a lot of therapeutic uses. The main components of Aristolochia indica are alkaloids, essential oils, bitter principles (aristolochin), fixed oil, tannic acid, resin, gum, and sugar. It works well to treat ulcers, bronchitis, asthma, and bites from insects and reptiles. Boerhavia diffusa is a well-known ethnomedical plant, a perennial creeping weed that grows in tropical and subtropical regions. The entire plant as well as leaves, roots, stems and plant extracts, has extensively employed in numerous traditional and folkloric medical systems for the treatment of a wide range of illnesses. The study mainly aims at the anti-inflammatory action of both Aristolochia indica and Boerhavia diffusa against the poisonous insect bites and stings. A transdermal patch is prepared by combining the extracts of Aristolochia indica and Boerhavia diffusa which seems to be another goal of this study. The Anti-inflammatory activity of the extracts are determined by Protein Denaturation Inhibition Test.

Keywords: Protein denaturation assay, Aristolochia indica, Boerhavia diffusa transdermal patches .