TO DEVELOP AND FORMULATION OF FLOATING TABLETS ALLOPURINOL TO ENHANCE THE BIOAVAILABILITY

Nikhil Pandey*, Praveen Kumar and Dr. Shamim Ahmed

ABSTRACT

Drug release and dissolution from the dose form retained in the stomach can occur at the stomach's pH below
strictly controlled parameters. One of the most extensively trained drug transport systems with stomach retentive
behavior is the floating system. Medication such as furosemide, ciprofloxacin, cyclosporine, and allopurinol should
take advantage of gastric maintenance. Medication whose solubility is lower in the higher pH of the small intestine
than the stomach (e.g., chlordiazepoxide and cinnarizine), medication prone to intestinal pH corruption (e.g.,
captopril), and medication for localized stomach exercise (e.g., misoprostol) can be administered as dose structures
with gastric maintenance. The dosage structure of HBS allows for the regulation of anti-infection drugs,
catecholamines, opioids, analgesics, anticonvulsants, muscle relaxants, antihypertensive drugs, and vitamins. The
following medications are listed as acceptable for use in the definition of coasting measurements buildings: drifting
drugs and capsules (acetaminophen, ampicillin, amoxycillin-trihydrate, diltiazem, fluorouracil, isosorbidemononitrate,
paraaminobenzoic corrosive, piretamide, theophylline, and verapamil hydrochloride, etc.); floating
microspheres (headache medicine, griseofulvin, p-nitro aniline, ibuprofen, terfinadine, and tranilast).

Keywords: Bioavailability, Allopurinol, Validation, Microspheres.