EVALUATION OF THE GASTROPROTECTIVE ACTIVITY OF LEAVES ETHANOLIC EXTRACT OF SENNA ALATA IN RAT MODEL

Aayush Tyagi*, Praveen Kumar and Dr. Shamim Ahmad

ABSTRACT

This research evaluates the antiulcer properties of Senna alata root extract by employing a mouse model of pylorus
ligation-induced ulcers. When given at dosages of 100, 200, and 300 mg/kg body weight over a five-day period,
Senna alata significantly decreased the ulcer index. The maximum degree of protection was seen at a dosage of 300
mg/kg. The extract markedly decreased the amount of stomach fluid, levels of free acidity, and levels of total
acidity, while concurrently elevating pH levels. In addition, it reduced the levels of pepsin and DNA, indicating a
reduction in cell discharge, while simultaneously increasing the concentration of mucosal glycoproteins and mucin
secretion. The findings suggest that Senna alata improves the protective function of the stomach mucosa, which is
similar to the effects of Ranitidine. This indicates that Senna alata might be a practical treatment choice for
managing ulcers.

Keywords: Ulcer, Senna, Ranitidine, Decoction, hyperacidity, Gastroprotective activity.