FORMULATION AND EVALUATION OF EFFECT OF YEMENI ALLIUM SATIVUM (GARLIC) EXTRACT IN TREATMENT OF ORAL CANDIDIASIS

Ahmed M. Al-Ghani, Mohammed A. Alkhawlani and Mahmoud Mahyoob Alburyhi*

ABSTRACT

Background: Allium Sativa is species of bulbous flowering plant that is very common in many countries, especially in Yemen. It has many uses, principally as food flavouring and traditional medicines. Objectives: The study aimed to test the effect of garlic on the treatment of oral ulcers and what dosage form will be suitable for using in mouth. Methods: The present study was carried out by extraction of active constituents of garlic bulbs and test their activity against fungi (Candida Albican) that regards one of the essential causes in mouth ulceration and healing of oral ulcers. Also formulating the garlic extract in suitable dosage form and performing some tests for stability of dosage form. Results: In the proposed studies, two garlic extracts (ethanol and distilled water) were highly effective against Candida Albican, the inhibition zone of two extract were 45 mm and 29 mm respectively, these results were more effective than standard antifungal nystatin with inhibition zone 23 mm, due to the high efficacy of ethanol extract, it was selected to prepare suitable oral dosage form to treat mouth ulcer and candidiasis. Conclusions: Based on the results obtained from this study, the two Yemeni garlic extracts were highly effective against Candida Albican, this efficacy was more than standard antifungal nystatin. The ethanol extract was more effective than water extract, so, this extract was selected to prepare suitable dosage form to treat mouth ulcer and mouth candidiasis.

Keywords: Allium Sativa, Candidiasis, Formulation, Garlic Extracts.