A RARE DAPSONE-RELATED LIFE-THREATENING HYPERSENSITIVITY SYNDROME IN A LEPROSY PATIENT

*Sushil Kumar Gaur MD and Suman Kumar Bharti DNB

ABSTRACT

Leprosy is a chronic infectious disease resulting from infection with the bacterium Mycobacterium lepra. It remains a significant public health problem in many parts of the world, particularly in developing countries like India, Indonesia, Nigeria, Bangladesh. Dapsone is a sulfone derivative that has been a cornerstone of multidrug therapy (MDT) for leprosy treatment since the 1940s (Mungroo et al., 2020). Some common adverse effects of dapsone include methemoglobinemia, hemolytic anemia, agranulocytosis, and hypersensitivity reactions (HRS) (Schifff et al., 2006). Life-threatening hypersensitivity reactions to dapsone are a rare but serious complication that needs prompt recognition and management.

Keywords: leprosy, DHS, Drug adverse effects.