EVALUATION OF THE ANTI-ULCER ACTIVITY OF ETHANOLIC LEAVES EXTRACT OF EUTERPE OLERACEA

Shivansh Singh*, Praveen Kumar and Dr. Shamim Ahmad

ABSTRACT

Peptic ulcers are a prevalent and widespread health issue. Primary reasons include an elevation in harmful
substances affecting the mucosal lining, a decrease in the body's ability to defend the mucosal lining, or the
generation of free radicals. Various plants and their derivatives, including Allium sativum, Bacopa monnieri,
Moringa oleifera, Aloe vera, Aegle marmelos, Carica papaya, Terminalia chebula, Sesbania grandiflora, Shorea
robusta, Azadirachta indica, Ocimum sanctum, Annona squamosa, Mimosa pudica, and several others, have
demonstrated the ability to prevent or treat peptic ulcers. The Euterpe oleracea plant was selected for assessment of
its anti-ulcer properties because it contains choline esters, which have the ability to regulate mucus production. The
plant is recognised for its many phytoconstituents, including as flavonoids, terpenoids, steroids, and coumarin. At
first, plant leaves were gathered and verified for authenticity. The Soxhlet device was used to do the extraction.
The pre-phytochemical screening indicated the presence of several phytoconstituents, such as flavonoids,
terpenoids, cardiac glycosides, steroids, and coumarin. The anti-ulcer effects of Euterpe oleracea leaves were
investigated using a model where ulcers were generated by aspirin. Pretreatment with the ethanolic extract of
Euterpe oleracea substantially lowered the ulcer index, free and total acidity, and glutathione GSH serum levels (p<
0.001). In addition, the levels of amylase, MDA, and amylase serum showed an increase. This was further
confirmed by histological examinations. In conclusion, our experiment showed that the ethanolic extract of Euterpe
oleracea has a similar ability to cure ulcers as the test substance. Therefore, this plant has the capacity to be used
for the purpose of identifying natural substances that may possibly serve as a reservoir of ideas for new
pharmaceutical goods.

Keywords: Peptic ulcers, Helicobacter pylori, Euterpe oleracea, Antacids.