FORMULATION, DEVELOPMENT AND EVALUATION OF FAST DISSOIVING TABLET CONTAINING SOLID DISPERSION OF MOSAPRIDE: A RESEARCH

*Namrata A. Chavan, Dr. Avish D. Maru, Dr. Majid Khann and Yashshri D. Sonawane

ABSTRACT

The dosage form's ability to transport the medication to the site of action at a rate and amount sufficient to produce the desired pharmacological response determines the drug's effectiveness. This dosage form characteristic is known as biologic availability, physiologic availability, or just bioavailability. Thus, the rate and amount of a medicine that remains unchanged from its dosage forms is referred to as its bioavailability. The in-vivo efficacy of medications taken orally is contingent upon their tissue permeability and solubility properties. The concept of solid dispersion was proposed by Sekiguchi and Obi in the early 1960’s, who investigated the generation and dissolution performance of eutectic, melts of a sulfonamide and water soluble carrier. Solid dispersion represents a useful pharmaceutical method for increasing the dissolution, absorption and therapeutic efficacy of the drug in the dosage forms. United States Food and Drug Administration (USFDA) defined fast dissolving tablet as “A solid dosage forms containing active ingredient or medical substances which disintegrates rapidly within a matter of seconds when placed upon the tongue.” The disintegration time for fast dissolving tablets ranges from few seconds to about a minute.

Keywords: Mosapride; Fast Dissolving Tablet; Solid Dispersion; Formulation Technique; Evaluation Methods; Appication.