A REVIEW ON FACTORS ASSOCIATED WITH THE DEVELOPMENT OF ALZHEIMER'S IN AUTISTIC PATIENTS

Ankita Anoop*, P. Jayashri Vidya, Srimathi M. and Margret Saral M.

ABSTRACT

Alzheimer's disease (AD) and Autism Spectrum Disorder (ASD) are two separate neurological disorders, each with their own pathophysiological characteristics. Newer evidence, however, points to a possible higher risk of AD development in those with ASD. The purpose of this review is to investigate the genetic, neuropathological, inflammatory, metabolic, cognitive, environmental, and psychosocial aspects linked to the onset of Alzheimer's disease in individuals with autism. We uncover common inflammatory pathways, shared neuropathological characteristics, and overlapping genetic markers that may contribute to the elevated risk by a thorough study of the literature that has already been published. Furthermore, we investigate how these two disorders interact with regard to metabolic dysfunction, behavioral and cognitive profiles, environmental exposures, and psychosocial stresses. The review also emphasizes the difficulties in diagnosing this particular patient population and the necessity of coordinated therapeutic approaches. Comprehending these variables is imperative in order to formulate focused interventions and enhance the standard of living for autistic individuals who are susceptible to Alzheimer's disease.

Keywords: Alzheimer's disease (AD), Autism Spectrum Disorder (ASD), Genetic factors, Neuropathology, Inflammation, Metabolic dysfunction, Cognitive decline, Environmental risk factors.