ANTIDIABETIC ACTIVITY OF SOME MEDICINAL PLANTS FROM SUBANG, WEST JAVA, INDONESIA: A REVIEW

Amelia Putri, Ananda Amelia Putri, Elsa Nurhalisa, Firda Nurazizah, Hana Taqqiyatul Labibah, Jingga Damayanti Iskandar, Krismawaty Sihole, Nadia Amelia, Najma Padhlatunnisa, Putri Latifah Nur Zahro, Rayninda Illysa Haqqi, Siti Nuraini Maulida, Sukmana Ikbal, Zahra Adisty Rahma, Zahra Khairunnisa, Maulana Yusuf Alkandahri*

ABSTRACT

Diabetes mellitus (DM), characterized by hyperglycemia, is a genetically and clinically heterogeneous group of disorders with the common feature of glucose intolerance. Type I (insulin-dependent diabetes mellitus), type II (non-insulin-dependent diabetes mellitus), other specific types, and gestational diabetes mellitus are the four primary subtypes of diabetes mellitus, as per the World Health Organization's recommendations. The cellular-mediated autoimmune destruction of pancreatic β cells is the cause of type 1 DM, or juvenile-onset diabetes. Contrarily, insulin resistance, typically leading to insulin deficiency, causes type 2 diabetes. Researchers are currently searching for novel anti-diabetic compound candidates derived from natural ingredients and empirically demonstrated to possess anti-diabetic properties. Researchers are doing this to replace anti-diabetic drugs, which are currently associated with a variety of side effects. This area in West Java, Indonesia, is home to many medicinal plants, such as Annona muricata, Artocarpus heterophyllus, Syzygium aromaticum, Nephelium lappaceum, Andrographis paniculata, Zingiber officinale, and Kaempferia galanga. Various mechanisms have scientifically demonstrated their anti-diabetic properties. Consequently, this review article examines the potential of numerous medicinal plants that are indigenous to Subang, West Java, Indonesia and possess anti-diabetic properties.

Keywords: Diabetes mellitus, Annona muricata, Artocarpus heterophyllus, Syzygium aromaticum, Nephelium lappaceum, Andrographis paniculata, Zingiber officinale, Kaempferia galanga.