CYTOKINE RESPONSE TO BACTERIAL TRANSLOCATION IN OLD WORLD MONKEYS MODEL OF IBD

Amaba Sima Tarielovna*, Konjaria Irina Georgievna, Trapsh Khamida Zurabovna, Dyachenko Anatoly G., Matua Alisa Zaurovna and Mikvabia Zurab Yasonovich

ABSTRACT

The development of inflammatory bowel diseases (IBD), representing various clinical and morphologic forms, is caused by the interaction of genetic, immunologic, and bacterial mechanisms. The cytokine response to bacterial translocation involved in the pathogenesis of the inflammatory process in the intestine was investigated on the model of experimental inflammation in nonhuman Macaque mulatta monkeys. Symptoms of inflammation were chemically induced by administration of 5% dextran sulfate. In response to induction, an increase in serum markers of translocation (16S rDNA and sCD14) and stimulation of cytokine response were recorded. The dynamics of cytokine response shows that the duration of DSS-induced inflammation is comparable to the time required for the transition of acute inflammation to chronic inflammation and is characterized predominantly by Th1 cytokine profile.

Keywords: Macaca mulatta, sodium dextran sulfate, microbial translocation, cytokines.