A REVIEW OF THE EXTENSIVE PHARMACOLOGICAL ACTIVITIES OF Terminalia chebula RETZ MEDIATED NANOPARTICLES

Shamiya Shirin K.B.* and Dr. Aiswarya Lakshmi AG and Hiba Muhammed

ABSTRACT

Terminalia chebula Retz (T. chebula), known as the King of Medicines, is a tree species belonging to the family Combretaceae that is widely used by Indian local communities to treat a variety of ailments. Terminalia chebula possesses various pleiotropic effects such as anti-oxidant, anti-diabetic, reno-protective, hepato-protective, anti-arthritic, cytoprotective, anti-microbial, anaphylactic effect, pro-kinetic effect, etc. Hence, T. chebula can be employed as a resourceful tool for green-synthesized nanoparticles that offer cost-effective, eco-friendly, high-yield, and sustained target delivery in contrast to conventional nanoparticle synthesis. In addition, the assessment of their pharmacological actions has shown the potential anti-microbial activity of silver, gold, and silver-palladium bimetallic nanoparticles synthesized from T. chebula. While silver, gold, and titanium dioxide nanoparticles have stronger anti-oxidant activities and are comparable to the standard treatments. Gold nanoparticles from T. chebula have more anti-inflammatory activity than the standard drug diclofenac. Furthermore, silver nanoparticles have demonstrated strong anti-urolithiatic, anti-cancer, and anti-phytopathogenic properties. Copper oxide nanoparticles have exhibited concentration-dependent anti-bacterial activity against wound pathogens. Silver, nickel oxide, and silver palladium bimetallic nanoparticles have displayed greater anti-cancer activity, and silver nanoparticles from T. chebula have shown a significant reduction in the IC50 value in comparison with T. chebula alone. The significance of T. chebula in green nanotechnology is highlighted by these findings, as well as the wide range and therapeutic potential of the nanoparticles made from it.

Keywords: Terminalia chebula Retz, Pharmacological activities, Nanotechnology, Green synthesis.